New CU study illuminates how cancer-killing gene may actually work.
Mary Allen
Postdoctoral Fellow
Scientists from the 乐播传媒 Cancer Center and the 乐播传媒 Boulder used a new technology to tease out how the p53 gene鈥恮hich is responsible for recognizing damaged DNA in cells and then marking them for death鈥恑s actually able to suppress tumors by determining what other genes p53 regulates. The study,聽, describes dozens of new genes directly regulated by p53.
The study authors say further research can explore which of these genes are necessary for p53鈥檚 cancer鈥恔illing effect, how cancer cells evade these p53鈥恆ctivated genes, and how doctors may be able to affect cancer cells鈥 ability to stay safe from these genetic attempts at suppression.
The exhaustively studied gene p53鈥恮hich has been the subject of 50,000 papers over more than 30 years of research鈥恑s the most commonly inactivated gene in cancers. When p53 acts, cells are stopped or killed before they can survive, grow, replicate and cause cancer.
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